Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$1,132,200.00
Vascular events in patients undergoing same-day noncardiac surgery (VALIANCE) - a prospective cohort and nested biobank study
EF 2020-21
Résumé
More than 1.8 million Canadians have same-day surgery every year. Same-day surgery used to be offered only to healthy patients having minor surgery, like cataract surgery. But in recent decades, more complex surgeries are performed as same-day procedures, often on older and sicker patients. In patients who have surgery and stay overnight in the hospital, studies have shown that cardiac complications are frequent and that most patients do not show any symptoms. Without routine blood work and follow-up after surgery, these events would go undetected. This raises the question: do patients who have surgery and are discharged home on the same day also suffer cardiac complications that are not recognized? Currently, clinicians do not have the tools to identify the frequency of cardiac complications or which patients are at higher risk. Routine blood tests done before and after surgery might be able to detect cardiac complications in patients undergoing same-day surgery. We propose to enroll adults from Canadian hospitals who are undergoing same-day surgery and will be monitored at 1 month and 3 months for the occurrence of cardiovascular complications. We aim to identify risk factors for a cardiovascular complication following a same-day surgery, and examine the impact on a patient's long-term health. We will also collect blood samples before and after surgery in a subgroup of patients with cardiovascular risk factors to determine if cardiac blood tests (i.e., NT-proBNP and troponin) can help identify those at higher risk of having a cardiac event and allow for early detection of these events. This study will enable us to develop tools allowing for better selection of patients eligible for a same-day surgery and improve management and surveillance of these patients in the future.
Programme
Project Grant
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
433931
Name
Duceppe Emmanuelle
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Clinical
Prcname2
Clinical Investigation - D: Cardiovascular Systems
Projecttitle
Vascular events in patients undergoing same-day noncardiac surgery (VALIANCE) - a prospective cohort and nested biobank study
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$1,132,200
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biobank; Myocardial Injury; Outpatient Surgery; Postoperative Complications; Prediction Model; Prospective Cohort
Abstract
More than 1.8 million Canadians have same-day surgery every year. Same-day surgery used to be offered only to healthy patients having minor surgery, like cataract surgery. But in recent decades, more complex surgeries are performed as same-day procedures, often on older and sicker patients. In patients who have surgery and stay overnight in the hospital, studies have shown that cardiac complications are frequent and that most patients do not show any symptoms. Without routine blood work and follow-up after surgery, these events would go undetected. This raises the question: do patients who have surgery and are discharged home on the same day also suffer cardiac complications that are not recognized? Currently, clinicians do not have the tools to identify the frequency of cardiac complications or which patients are at higher risk. Routine blood tests done before and after surgery might be able to detect cardiac complications in patients undergoing same-day surgery. We propose to enroll adults from Canadian hospitals who are undergoing same-day surgery and will be monitored at 1 month and 3 months for the occurrence of cardiovascular complications. We aim to identify risk factors for a cardiovascular complication following a same-day surgery, and examine the impact on a patient's long-term health. We will also collect blood samples before and after surgery in a subgroup of patients with cardiovascular risk factors to determine if cardiac blood tests (i.e., NT-proBNP and troponin) can help identify those at higher risk of having a cardiac event and allow for early detection of these events. This study will enable us to develop tools allowing for better selection of patients eligible for a same-day surgery and improve management and surveillance of these patients in the future.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Duceppe, Emmanuelle
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,132,200~ $0~