Grant: Team Grant: Mental Disorders

The lack of control of impulsivity (i.e. Impulse Control Disorders; ICD) can lead to various disorders that encompass drug addiction, pathological gambling, compulsive shopping, binge eating, hypersexuality. In the past years, the role of the subthalamic nucleus (STN) in impulsivity has been highlighted. The STN is the current target for the surgical treatment of Parkinson's Disease using Deep Brain Stimulation (DBS). Interestingly, PD is a disease often associated with ICD. The aim of the present project is thus to characterise the effects of STN DBS in various forms of ICD in intact rats and assessed in various behavioural tasks measuring impulsive choice, gambling and addiction. The studies carried out in rats will be paralleled by clinical studies characterizing the effects of STN DBS applied in PD patients on ICD, measured in various tasks such as Go/NoGo and the Iowa gambling task. This project, bringing together experts in rat STN, impulsivity and clinical experts of STN DBS in patients, should lead to a better understanding of STN contribution in ICD processes and may also lead to a more refined prescription of STN DBS for the treatment of ICD.