Grant: CIHR - ICR / Cancer Research Society Partnership - Research Grants
Research Institute of the McGill University Health Centre
$50,765.00
Studying the biology and clinical utility of aberrantly expressed cancer testis, and embryonic stem cell genes for the treatment of advanced/recurrent NMSCs.
EF 2019-20
Résumé
Basal cell and skin squamous cell carcinomas, collectively known as Non-Melanoma Skin Cancers (NMSCs) or keratinocyte carcinomas, are the most common human cancers. There are very few treatment options available for patients with advanced NMSCs. How these cancers develop remains only partially understood. In this research we propose to use United Kingdom (UK) Biobank to study gene-environment interactions contributing to the development of invasive skin cancers. We will also identify aberrantly expressed genes (cancer testis, meiosis CT and embryonic stem cell genes) in multiple cohorts of NMSC patients with advanced or recurrent tumours with already available sequencing data. We will validate these gene targets in our cohort of >240 NMSC samples by molecular biology approaches to determine gene/protein expression levels. We will also study the function of select genes in cancer cells and how their activity can make NMSCs more aggressive. This research will help identify new avenues for treating NMSCs/keratinocyte carcinomas.
Programme
CIHR - ICR / Cancer Research Society Partnership - Research Grants
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
422055
Name
Litvinov Ivan V
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Cancer Research Society Inc.; Cancer Research Society Inc.
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Special Cases
Projecttitle
Studying the biology and clinical utility of aberrantly expressed cancer testis, and embryonic stem cell genes for the treatment of advanced/recurrent NMSCs.
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$50,765
Cihrequipment2
$0
Programname2
CIHR - ICR / Cancer Research Society Partnership - Research Grants
Keyworddelim
Basal Cell Carcinoma; Cancer Testis Genes; Gene Expression Profiling; Gene-Environment Interactions; Mendelian Randomization; Non-Melanoma Skin Cancers; Risk Factors; Squamous Cell Carcinoma; Targeted Therapies; Uk Biobank
Abstract
Basal cell and skin squamous cell carcinomas, collectively known as Non-Melanoma Skin Cancers (NMSCs) or keratinocyte carcinomas, are the most common human cancers. There are very few treatment options available for patients with advanced NMSCs. How these cancers develop remains only partially understood. In this research we propose to use United Kingdom (UK) Biobank to study gene-environment interactions contributing to the development of invasive skin cancers. We will also identify aberrantly expressed genes (cancer testis, meiosis CT and embryonic stem cell genes) in multiple cohorts of NMSC patients with advanced or recurrent tumours with already available sequencing data. We will validate these gene targets in our cohort of >240 NMSC samples by molecular biology approaches to determine gene/protein expression levels. We will also study the function of select genes in cancer cells and how their activity can make NMSCs more aggressive. This research will help identify new avenues for treating NMSCs/keratinocyte carcinomas.
Competitiondate
202002
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Litvinov, Ivan V
Approvedterm
2 ans 0 mois
Cihrcontribution2
Inst of Musculoskel Hlth &Arth~ $50,765~ $0~
