Grant: Project Grant
Queen's University (Kingston, Ontario)
$481,952.00
Local pro-angiogenic peptide delivery for treating critical limb ischemia
EF 2021-22
Résumé
Blockages in the arteries that feed the muscles in the lower leg can lead to decreased function and a compromised ability to fight infection. In some circumstances, the patient may end up with an uncontrolled infection, with the result that a surgeon must amputate the leg. To eliminate this problem, in this project, we will develop a drug delivery system that causes new blood vessels to form around the blockage in the artery. These new blood vessels will return the efficacy of the immune system and prevent the need for amputations.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
445225
Name
Amsden Brian G
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
Local pro-angiogenic peptide delivery for treating critical limb ischemia
Programtype2
Operating Grants
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$481,952
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Degradable Polymer; Local Drug Delivery; Pharmaceutics; Therapeutic Angiogenesis; Vegf Mimic Peptide
Abstract
Blockages in the arteries that feed the muscles in the lower leg can lead to decreased function and a compromised ability to fight infection. In some circumstances, the patient may end up with an uncontrolled infection, with the result that a surgeon must amputate the leg. To eliminate this problem, in this project, we will develop a drug delivery system that causes new blood vessels to form around the blockage in the artery. These new blood vessels will return the efficacy of the immune system and prevent the need for amputations.
Competitiondate
202104
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Amsden, Brian G
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $481,952~ $0~
