Grant: Rapid Funding for DSEN Targeted Research

Epilepsy is a condition in which the individual experiences recurrent seizures. It is the most common chronic neurological condition, affecting 0.6 to 1% of the population. Antiepileptic drugs (AEDs) can prevent seizures and avoid their consequences. Given that approximately 1/3 of people receiving AEDs are of reproductive age and almost half of pregnancies are unplanned, the fetus may be exposed to AEDs in the first trimester of pregnancy, which is the critical stage of fetal organ differentiation and development. Many AEDs can cross the placenta and therefore pose risks to the fetus including major congenital malformations, minor anomalies, fetal growth restriction, early cognitive and developmental delays, and infant mortality amongst others. This review will provide information to Health Canada, women and their health care providers about these risks and will facilitate evidence-informed decision making.