Grant: Alliance Grants
University of Prince Edward Island
$65,000.00
Hydrogel constructs to improve the stability of biologics in industrial applications
EF 2023-24
Résumé
This project aims at developing novel hydrogel coating technology to improve the development, purification and shelf life of active pharmaceutical ingredients (APIs) including proteins and nucleic acids at ambient temperatures. This will be achieved by coating commercially available glass vials and chromatography resins with poly(vitamin B5 analogous methacrylamide) poly(B5AMA) hydrogels. The hydrogels coated resins will be included in production batches of APIs to improve the stability of bioactives under harsh synthesis procedure. The bioactives manufactured will be stored in hydrogels coated glass vials to ensure longer shelf life of the products at ambient temperatures. Poly(B5AMA) hydrogels coating on glass vials is expected to provide a convenient commercialization strategy for the facile synthesis, transport, storage and usage of active pharmaceutical therapeutics in research laboratories, pharmaceutical companies and in health care settings.
Programme
Alliance Grants
Bénéficiaire
Emplacement
Prince Edward Island, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
571922-2022
Name nom
Ahmed, Marya M
Department département
Chemistry
Organization id
88
Institution établissement
University of Prince Edward Island
Province en
Prince Edward Island
Province fr
Île-du-Prince-Édouard
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2022
Award amount
65000
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
1208
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Materials sciences
Area of application fr
Sciences des matériaux
Research subject code
1900
Research subject group en
Biomedical engineering
Research subject group fr
Biomedical engineering
Research subject en
Génie biomédical
Research subject fr
Génie biomédical
Application title
Hydrogel constructs to improve the stability of biologics in industrial applications
Keyword
hydrogels; nucleic acid stabilization; protein denaturation; protein refolding; protein stabilization
Application summary
This project aims at developing novel hydrogel coating technology to improve the development, purification and shelf life of active pharmaceutical ingredients (APIs) including proteins and nucleic acids at ambient temperatures. This will be achieved by coating commercially available glass vials and chromatography resins with poly(vitamin B5 analogous methacrylamide) poly(B5AMA) hydrogels. The hydrogels coated resins will be included in production batches of APIs to improve the stability of bioactives under harsh synthesis procedure. The bioactives manufactured will be stored in hydrogels coated glass vials to ensure longer shelf life of the products at ambient temperatures. Poly(B5AMA) hydrogels coating on glass vials is expected to provide a convenient commercialization strategy for the facile synthesis, transport, storage and usage of active pharmaceutical therapeutics in research laboratories, pharmaceutical companies and in health care settings.
