Grant: Operating Grant - PA: Institute of Genetics (Bridge Funding)
York University (Toronto, Ontario)
$100,000.00
Regulation of MEF2 activity in cardiac and skeletal muscle
EF 2008-09
Résumé
Specific patterns of gene expression underlie development of the heart and skeletal muscle. In addition, disease can lead to inappropiate alterations in gene expression that can lead to negative changes in these tissues that compromise function, such as the ability of the heart to pump blood efficiently to peripheral tissues. The proposed work is designed to understand the fundamentals of how gene expression is controlled during muscle development and how this knowledge might be harnessed to limit disease related changes in the adult.
Programme
Operating Grant - PA: Institute of Genetics (Bridge Funding)
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
177926
Name
McDermott John C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Cardiovascular System - A: Cells and Tissues
Projecttitle
Regulation of MEF2 activity in cardiac and skeletal muscle
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Operating Grant - PA: Institute of Genetics (Bridge Funding)
Keyworddelim
Cardiac Hypertrophy; Cardiac Muscle; Gene Expression; Mef2; Proteomics; Transcription
Abstract
Specific patterns of gene expression underlie development of the heart and skeletal muscle. In addition, disease can lead to inappropiate alterations in gene expression that can lead to negative changes in these tissues that compromise function, such as the ability of the heart to pump blood efficiently to peripheral tissues. The proposed work is designed to understand the fundamentals of how gene expression is controlled during muscle development and how this knowledge might be harnessed to limit disease related changes in the adult.
Competitiondate
200809
Approvedterm2
1 yr 0 mth
Pinamesdelim
McDermott, John C
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
