Grant: Project Grant
McGill University
$864,450.00
Counteracting type 2 immunopathologies through modulation of lipid metabolism
EF 2020-21
Résumé
The type 2 immune response is critical for host defense against large parasites such as helminths, wound healing and body metabolism. On the other hand, dysregulation of type 2 immunity causes immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis, which have been referred to as type 2 immunopathologies. Thus, a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding immunopathology. We identified that two proteins involved in lipid metabolism exert important functions during type 2 immune response. The proposed research aims to decipher the mechanisms of lipid metabolism for the regulation of type 2 immune responses and assess the capacity of novel drug treatment strategies for type 2 immunopathologies.
Programme
Project Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
434297
Name
Fritz Jorg H
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Counteracting type 2 immunopathologies through modulation of lipid metabolism
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$864,450
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Allergic Lung Inflammation; Asthma; Clinically Approved Small Molecule Inhibitors; Diglyceride Acyltransferase 2 (Dgat2); Group 2 Innate Lymphoid Cells (Ilc2); Lipid Metabolism; Peroxisome Proliferator-Activated Receptor (Ppar)-Alpha; Th2 Cells; Triglyceride Synthesis; Type 2 Immunity
Abstract
The type 2 immune response is critical for host defense against large parasites such as helminths, wound healing and body metabolism. On the other hand, dysregulation of type 2 immunity causes immunopathological conditions, including asthma, atopic dermatitis, rhinitis, and anaphylaxis, which have been referred to as type 2 immunopathologies. Thus, a balanced type 2 immune response must be achieved to mount effective protection against invading pathogens while avoiding immunopathology. We identified that two proteins involved in lipid metabolism exert important functions during type 2 immune response. The proposed research aims to decipher the mechanisms of lipid metabolism for the regulation of type 2 immune responses and assess the capacity of novel drug treatment strategies for type 2 immunopathologies.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Fritz, Jorg H
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $864,450~ $0~
