Grant: Engage Grants Program
Brock University
$24,523.00
Development of high-yielding stereoselective methodologies for the synthesis of Active Pharmaceutical Ingredients (API)
EF 2014-15
Résumé
The proposed collaborative project with Alphora Research involves the development of synthetic processes for manufacturing precursors for a group of chemical compounds called halichondrin polycyclic macrolides, which have potential as cancer drugs. These anti-tumour substances are related to halichondrin B, a natural product that was isolated from a marine sponge. Health Canada and the FDA have recently approved the fully synthetic analog eribulin for treatment of certain metastatic breast cancers; however, the manufacturing process is not yet efficient for this and related substances. We will focus our efforts in improving the methodologies for some of the steps in the preparation of this medicinally important group of compounds.
Programme
Engage Grants Program
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
462733-2014
Name nom
Dudding, Travis
Department département
Chemistry
Organization id
22
Institution établissement
Brock University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2014
Competition year année de concours
2014
Award amount
24523
Program id
EGP
Program name en
Engage Grants Program
Program name fr
Programme de subventions d'engagement partenariat
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1553
Committee name en
Ontario Internal Decision Committee
Committee name fr
Comité de décision interne pour l'Ontario
Area of application code
504
Area of application group en
Manufacturing processes and products
Area of application group fr
Procédés et produits industriels
Area of application en
Human pharmaceuticals
Area of application fr
Produits pharmaceutiques administrables à l'homme
Research subject code
3704
Research subject group en
Organic chemistry
Research subject group fr
Chimie organique
Research subject en
Synthetic methodology
Research subject fr
Méthodologie en synthèse
Partie
1
Nb partie
1
Application title
Development of high-yielding stereoselective methodologies for the synthesis of Active Pharmaceutical Ingredients (API)
Keyword
NSERC
Application summary
The proposed collaborative project with Alphora Research involves the development of synthetic processes for manufacturing precursors for a group of chemical compounds called halichondrin polycyclic macrolides, which have potential as cancer drugs. These anti-tumour substances are related to halichondrin B, a natural product that was isolated from a marine sponge. Health Canada and the FDA have recently approved the fully synthetic analog eribulin for treatment of certain metastatic breast cancers; however, the manufacturing process is not yet efficient for this and related substances. We will focus our efforts in improving the methodologies for some of the steps in the preparation of this medicinally important group of compounds.
