Grant: Operating Grant

Macrophages and lymphocytes are uniquely situated and suited for a modifier role in iron metabolism, either directly or through mediating molecules, which they produce. We will study the influence of immune system components, such as receptors, cell types and immune mediators, and identify the contribution of signaling pathways to the maintenance of iron homeostasis. These studies could potentially have important therapeutic applications not only in the management of iron overload, but also in treating conditions such as anemia and other iron-related diseases. Moreover, they will provide a better understanding of some basic aspects of the immune system and their relationship to the fundamental process of iron metabolism.