Grant: Operating Grant
University of Ottawa
$681,270.00
Neural and biochemical correlates of resting state activity and emotional processing in major depressive disorder - Multimodal imaging (fMRI, MRS and PET) during gaba- and glutamat-ergic intervention
EF 2010-11
Résumé
Major depressive disorder (MDD) is a prominent psychiatric disorder which is projected to be the second most often occurring illness (after cardiac disorders) in about 10 years, world-wide. Clinically, MDD can be characterized by strong ruminations, enhanced feelings of guilt and self-blame, abnormally negative emotions, and increased attention to one's self, e.g., increased self-focus [1-3]. These symptoms can be treated with serotoninergic drugs as well as with GABAergic and glutamatergic drugs like lorazepam and ketamine. While there has been much research about the serotoninergic system, the mechanisms underlying GABA- and glutamatergic dysfunction in MDD remain to be explored and are the target of our study proposal.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
224625
Name
Northoff Georg F
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Clinical
Prcname2
Behavioural Sciences - B: Clinical Behavioural Sciences
Projecttitle
Neural and biochemical correlates of resting state activity and emotional processing in major depressive disorder - Multimodal imaging (fMRI, MRS and PET) during gaba- and glutamat-ergic intervention
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$681,270
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Brain Imaging In Humans; Depression; Gaba; Glutamate; Prefrontal Cortex
Abstract
Major depressive disorder (MDD) is a prominent psychiatric disorder which is projected to be the second most often occurring illness (after cardiac disorders) in about 10 years, world-wide. Clinically, MDD can be characterized by strong ruminations, enhanced feelings of guilt and self-blame, abnormally negative emotions, and increased attention to one's self, e.g., increased self-focus [1-3]. These symptoms can be treated with serotoninergic drugs as well as with GABAergic and glutamatergic drugs like lorazepam and ketamine. While there has been much research about the serotoninergic system, the mechanisms underlying GABA- and glutamatergic dysfunction in MDD remain to be explored and are the target of our study proposal.
Competitiondate
201103
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Northoff, Georg F
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $681,270~ $0~
