Grant: China-Canada Joint Health Research Initiative
University of British Columbia
$150,000.00
High-throughput screening and identification of anti-TB compounds from a unique natural product library
EF 2008-09
Résumé
Among infectious diseases, tuberculosis (TB) is the major leading
cause of death in the world, killing 3,000,000 people annually. Due
to the rapid development of extreme drug resistance TB there is an
urgent need to find new anti mycobacterial agents. The proposed
collaborative research seeks to take advantage of the large
collection actinomycetes and fungal strains from un- or under-
explored ecological niches in China, none of which has been
previously screened for antimicrobial activity. The Collection is
available at the Institute of Microbiology in the Chinese Academy of
Sciences in Beijing will be used to identify both target specific and
cell based lead compounds against TB. Lead compounds will be
evaluated for their activity and cytotoxicity in human macrophages.
Programme
China-Canada Joint Health Research Initiative
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
182651
Name
Av-Gay Yossef
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
National Natural Science Foundation of China (Haidian, Beijing)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
China-Canada Joint Health Research Initiative - Grants Program
Projecttitle
High-throughput screening and identification of anti-TB compounds from a unique natural product library
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
China-Canada Joint Health Research Initiative
Keyworddelim
Hts; Natural Products; Tuberculosis
Abstract
Among infectious diseases, tuberculosis (TB) is the major leading
cause of death in the world, killing 3,000,000 people annually. Due
to the rapid development of extreme drug resistance TB there is an
urgent need to find new anti mycobacterial agents. The proposed
collaborative research seeks to take advantage of the large
collection actinomycetes and fungal strains from un- or under-
explored ecological niches in China, none of which has been
previously screened for antimicrobial activity. The Collection is
available at the Institute of Microbiology in the Chinese Academy of
Sciences in Beijing will be used to identify both target specific and
cell based lead compounds against TB. Lead compounds will be
evaluated for their activity and cytotoxicity in human macrophages.
Competitiondate
200903
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Av-Gay, Yossef
Approvedterm
3 ans 0 mois
Cihrcontribution2
Inst of Infection & Immunity~ $150,000~ $0~
