Grant: Project Grant
University of Toronto
$875,925.00
The neural and glial bases of diet-induced deficits in control of reward-seeking actions
EF 2023-24
Résumé
Attempts to lose weight typically fail over the long term despite strong motivation and determined efforts. We recently found that excess sugar and fat in the diet promotes reliance on habits at the expense of more flexible decision-making based on the value of outcomes produced by behaviour. The aim of this project is to understand how diet-induced obesity impacts brain circuits that control flexible and habitual behaviours which in turn prevent sound eating choices and undermine enduring weight loss efforts. It will help identify novel therapies to restore flexible decision-making, for improved management of diet and weight.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
490692
Name
Corbit Laura
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - A: Neurobiological Basis of Behavioural Processes
Projecttitle
The neural and glial bases of diet-induced deficits in control of reward-seeking actions
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$875,925
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Diet-Induced Obesity; Dorsal Striatum; Goal-Directed Learning; Habit Learning; Instrumental Learning
Abstract
Attempts to lose weight typically fail over the long term despite strong motivation and determined efforts. We recently found that excess sugar and fat in the diet promotes reliance on habits at the expense of more flexible decision-making based on the value of outcomes produced by behaviour. The aim of this project is to understand how diet-induced obesity impacts brain circuits that control flexible and habitual behaviours which in turn prevent sound eating choices and undermine enduring weight loss efforts. It will help identify novel therapies to restore flexible decision-making, for improved management of diet and weight.
Competitiondate
202309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Corbit, Laura
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $875,925~ $0~
