Grant: Operating Grant

During brain development, neurons navigate over long or short distances to reach their targets and make the appropriate neural connections. To achieve this important task, they will be guided by molecular cues present in their cellular environment. Netrins are guiding neurons during brain development. In this research proposal, our goals are to understand how netrin-1 regulate the navigation of neurons and what are the molecular targets of netrin-1. Understanding the molecular mechanisms underlying netrin-1 function will help to identify novel therapeutic strategies for tumor therapy, neurodegenerative diseases, and spinal cord injuries.