Grant: Operating Grant
Université de Sherbrooke
$607,899.00
Structural determinants for the activation of the chemokine receptor CXCR4
EF 2009-10
Résumé
Understanding the molecular machinery of the HIV co-receptor CXCR4 is essential for the successful development of improved HIV drugs with less side effects and resistance development. CXCR4 is not only a target of HIV infection but is also essential for the correct development of the foetus and control of the immune system, therefore drugs are to be developed that do not interfere with the normal functions. The present project is aimed towards this goal by elucidating the molecular machinery of the system.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
200640
Name
Escher Emanuel
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Pharmacology & Toxicology
Projecttitle
Structural determinants for the activation of the chemokine receptor CXCR4
Programtype2
Operating Grants
Orgnameinp2
Université de Sherbrooke
Cihramount2
$607,899
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cxcl12; Cxcr4; Methionine Proximity Assay; Peptide Synthesis; Photoaffinity Labelling; Sdf1; Site-Directed Mutagenesis
Abstract
Understanding the molecular machinery of the HIV co-receptor CXCR4 is essential for the successful development of improved HIV drugs with less side effects and resistance development. CXCR4 is not only a target of HIV infection but is also essential for the correct development of the foetus and control of the immune system, therefore drugs are to be developed that do not interfere with the normal functions. The present project is aimed towards this goal by elucidating the molecular machinery of the system.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Escher, Emanuel
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $607,899~ $0~
