Grant: Operating Grant
Université Laval
$742,371.00
Functions of the tumor suppressor PALB2 in DNA double-strand break repair and tumorigenesis
EF 2010-11
Résumé
Mutations in the BRCA1 and BRCA2 genes strongly predispose to breast cancer. PALB2 is a BRCA2 interacting protein that has been newly identified. Individuals who inherit PALB2 alterations have a risk of developing breast cancer. For instance, a novel truncating mutation in PALB2 was found in approximately 0.5% of unselected French-Canadian women with early-onset breast cancer. Interestingly, defects in BRCA2 and PALB2 cause a defect in homologous recombination, an important process to repair DNA damage within the cell. We aim to understand how the DNA repair proteins affect the cell ability to repair DNA by homologous recombination and then use this knowledge to design new therapies to reduce cellular viability of cancer cells.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
210642
Name
Masson Jean-Yves
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Functions of the tumor suppressor PALB2 in DNA double-strand break repair and tumorigenesis
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$742,371
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Biochemical And Cellular Assays; Brca2; Breast Cancer Research; Dna Repair; Double-Strand Breaks; Fanconi Anemia; Palb2; Pancreatic Cancer
Abstract
Mutations in the BRCA1 and BRCA2 genes strongly predispose to breast cancer. PALB2 is a BRCA2 interacting protein that has been newly identified. Individuals who inherit PALB2 alterations have a risk of developing breast cancer. For instance, a novel truncating mutation in PALB2 was found in approximately 0.5% of unselected French-Canadian women with early-onset breast cancer. Interestingly, defects in BRCA2 and PALB2 cause a defect in homologous recombination, an important process to repair DNA damage within the cell. We aim to understand how the DNA repair proteins affect the cell ability to repair DNA by homologous recombination and then use this knowledge to design new therapies to reduce cellular viability of cancer cells.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Masson, Jean-Yves
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $742,371~ $0~
