Grant: Operating Grant
University of British Columbia
$781,855.00
Leptin Regulation of Glucose Homeostasis
EF 2011-12
Résumé
We have found a link between leptin, the so-called obesity hormone and tissues that regulate blood sugar levels. Mice with a genetic defect in the leptin gene eventually develop obesity and a syndrome resembling type 2 diabetes. This condition disappears when the mutant mice are treated with leptin. Remarkably, leptin can also effectively treat diabetes that is not associated with obesity (type 1 diabetes). The goal of our research is to determine how leptin lowers blood sugar levels. We will explore the contributions of leptin actions on multiple tissues in the body as well as the brain, which could reveal novel strategies to treat diabetes.
Programme
Operating Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
254532
Name
Kieffer Timothy J
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Leptin Regulation of Glucose Homeostasis
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$781,855
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Diabetes; Glucose; Insulin; Islet; Leptin; Transgenic
Abstract
We have found a link between leptin, the so-called obesity hormone and tissues that regulate blood sugar levels. Mice with a genetic defect in the leptin gene eventually develop obesity and a syndrome resembling type 2 diabetes. This condition disappears when the mutant mice are treated with leptin. Remarkably, leptin can also effectively treat diabetes that is not associated with obesity (type 1 diabetes). The goal of our research is to determine how leptin lowers blood sugar levels. We will explore the contributions of leptin actions on multiple tissues in the body as well as the brain, which could reveal novel strategies to treat diabetes.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kieffer, Timothy J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $781,855~ $0~
