Grant: Operating Grant
Memorial University of Newfoundland
$727,305.00
Formate: key to fetal one-carbon metabolism
EF 2014-15
Résumé
Two vitamins, (folate and vitamin B12) which are essential for the proper growth and development of infants in the womb work by means of a very simple molecule called formate. Formate is related to formic acid which is found in the stings of ants. We propose to discover why high levels of formate in the developing baby are important, how they arise, where they go, and what they do. In addition to preventing neural tube defects such as spina bifida, the research raises the possibility that formate may be useful in the prevention of other developmental disorders, particularly those caused by placental insufficiency. Therefore, formate may improve the personal health of both young and older Canadians and of populations worldwide.
Programme
Operating Grant
Bénéficiaire
Emplacement
Newfoundland and Labrador, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
320320
Name
Brosnan John (Sean) T
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Nutrition, Food & Health
Projecttitle
Formate: key to fetal one-carbon metabolism
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$727,305
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Folate; Mitochondria; One-Carbon Metabolism; Placenta; Vitamin B12
Abstract
Two vitamins, (folate and vitamin B12) which are essential for the proper growth and development of infants in the womb work by means of a very simple molecule called formate. Formate is related to formic acid which is found in the stings of ants. We propose to discover why high levels of formate in the developing baby are important, how they arise, where they go, and what they do. In addition to preventing neural tube defects such as spina bifida, the research raises the possibility that formate may be useful in the prevention of other developmental disorders, particularly those caused by placental insufficiency. Therefore, formate may improve the personal health of both young and older Canadians and of populations worldwide.
Competitiondate
201503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Brosnan, John (Sean) T
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $727,305~ $0~
