Grant: Operating Grant
University of Toronto
$947,528.00
Mechanisms of Genome Instability
EF 2013-14
Résumé
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells. These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how they arise could lead to improvements in cancer detection and treatment. We will study how proteins help copy the DNA, and how proteins prevent mistakes during the copying of the DNA.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
290460
Name
Brown Grant W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Mechanisms of Genome Instability
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$947,528
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bloom'S Syndrome; Cancer; Dna Replication; Functional Genomics; Genome Instability; Replication Stress; Yeast Genetics
Abstract
Before a cell can grow and divide it must duplicate its DNA. Mistakes during the copying of the DNA can lead to the kinds of changes that are frequently seen in cancerous cells. These changes are important for cancer development, progression, and treatment, but there is little information about how they arise. Understanding how they arise could lead to improvements in cancer detection and treatment. We will study how proteins help copy the DNA, and how proteins prevent mistakes during the copying of the DNA.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Brown, Grant W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $947,528~ $0~
