Grant: Project Grant

Proteoglycan 4 (Prg4), also known as lubricin, is a critical protein that protects tissues and promotes healing. While Prg4 is well-known for its role in joint lubrication, recent discoveries suggest it is also produced by the liver and may influence wound healing, immune responses, and blood clotting. This project explores how liver-derived Prg4 helps maintain tissue health and how its breakdown by specific enzymes may contribute to disease. Using advanced genetic models and cutting-edge proteomics, we aim to uncover how Prg4 supports liver function, regulates healing, and affects coagulation. Understanding these mechanisms could lead to new treatments for liver diseases, fibrosis, and blood clotting disorders. Our findings have broad implications for regenerative medicine and could pave the way for innovative therapies to enhance healing and prevent chronic disease. By identifying the factors that regulate Prg4, we hope to develop targeted interventions that improve patient outcomes and overall health.