Grant: Operating Grant

The overall benefit of this project will be to help explain why people get osteoarthritis, which must be understood to develop ways to prevent and treat the disease. The aims of this project are a) to develop new methods for measuring how knees move and transmit load b) to develop new methods for measuring early degeneration in cartilage and c) to assess how the changes in joint movement and load transmission produced by an operation performed for early osteoarthritis are linked to degeneration of cartilage. To date, these links have not been well-studied because we have not previously been able to make appropriate measurements of joint movement and load transmission and cartilage degeneration in living people.