Grant: Catalyst Grant: Analysis of CLSA Data
Centre hospitalier de l'Université de Montréal (CHUM)
$70,000.00
Graphical Models and Mendelian randomization to characterize and validate grip strength as well as other measures of frailty in cardiovascular disease
EF 2018-19
Résumé
Evidence suggests that a strong or weak hand grip may help measure an individual's risk for developing a cardiovascular disease, regardless of their age or the country they live in. Grip strength can be measured easily in a physician office and may help identify individuals at high risk of cardiovascular disease and indicate who may need an intervention. One hypothesis explaining the link between grip strength and cardiovascular disease is that grip strength is a measure of how well one's body is functioning, also known as frailty. However, our understanding of the mechanisms explaining why grip strength may predict the occurrence of cardiovascular disease is currently limited. We will use data from the Canadian Longitudinal Study on Aging, which collected data on more than 50 thousand Canadian aged 45 years and higher, to better understand the associations between grip strength and the risk factors associated with cardiovascular disease. We will also assess whether alternative measures of frailty are more associated with cardiovascular risk than grip strength.
Programme
Catalyst Grant: Analysis of CLSA Data
Emplacement
Quebec, Canada
Type de bénéficiaire
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
389508
Name
Sylvestre Marie-Pierre
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Social / Cultural / Environmental / Population Health
Prcname2
Catalyst Grant: Analysis of CLSA Data
Projecttitle
Graphical Models and Mendelian randomization to characterize and validate grip strength as well as other measures of frailty in cardiovascular disease
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$70,000
Cihrequipment2
$0
Programname2
Catalyst Grant: Analysis of CLSA Data
Keyworddelim
Blood Pressure; Cardiovascular Disease; Frailty; Graphical Models; Grip Strength; Mendelian Randomization; Single Nucleotide Polymorphisms
Abstract
Evidence suggests that a strong or weak hand grip may help measure an individual's risk for developing a cardiovascular disease, regardless of their age or the country they live in. Grip strength can be measured easily in a physician office and may help identify individuals at high risk of cardiovascular disease and indicate who may need an intervention. One hypothesis explaining the link between grip strength and cardiovascular disease is that grip strength is a measure of how well one's body is functioning, also known as frailty. However, our understanding of the mechanisms explaining why grip strength may predict the occurrence of cardiovascular disease is currently limited. We will use data from the Canadian Longitudinal Study on Aging, which collected data on more than 50 thousand Canadian aged 45 years and higher, to better understand the associations between grip strength and the risk factors associated with cardiovascular disease. We will also assess whether alternative measures of frailty are more associated with cardiovascular risk than grip strength.
Competitiondate
201809
Approvedterm2
1 yr 0 mth
Pinamesdelim
Sylvestre, Marie-Pierre; Keezer, Mark
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $70,000~ $0~