Grant: Research Tools and Instruments - Category 1 (<$150,000)
University of Waterloo
$143,967.00
A microscale velocity measurement system for lab-on-a-chip applications
EF 2006-07
Résumé
The proposed research aims to develop micro-PIV technology for Lab-on-a-Chip (LOC) applications. A typical Lab-on-a-Chip device is a piece of glass or plastic plate with multiple chemical or biomedical laboratories integrated on it to perform micro-total-analysis. Lab-on-a-Chip devices have many advantages over their traditional counterparts including reduced expensive sample and reagent use, reduced processing time and space requirements, increased throughput and portability, and potentials for point-of-care diagnostics and treatment. However, the development of such attractive devices has been largely hindered due to the lack of the tools for precise design and operational control of the microfluidic platform, which holds and connects all the components of a LOC device. The major difficulty originates from the flow control of the microfluidic platform, which is dependent on solid-liquid interface properties. LOC devices include several components for sample preparation, mixing, dispensing, separation and detection, involving a variety of chemical solutions, biological samples, and chip materials. Therefore, the development of such devices requires a large database of the flow field information for each pair of solid-liquid interfaces. In addition, complex channel geometries and channel layouts make the flow field on a chip very complicated and the flow control very difficult. Micro particle image velocimetry is the only method for flow field measurement in the microscale and is essential for the development of LOC devices with the goal of developing point-of-care diagnostic instruments. The micro-PIV system, requested in this application, will provide urgently needed analytical resources to the research programs of Carolyn Ren and David Johnson. This setup will allow direct velocity measurement of the flow field in various microfluidic chips involving a variety of chemical solutions and samples. Fluorescent particles will be excited by a laser source and then detected by a CCD camera. The stored images will be analyzed using software on a computer to obtain the flow field.
Programme
Research Tools and Instruments - Category 1 (<$150,000)
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
345381-2007
Name nom
Ren, Carolyn
Department département
Mechanical Engineering & Mechatronics
Organization id
33
Institution établissement
University of Waterloo
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2006
Competition year année de concours
2007
Award amount
143967
Program id
EQPEQ
Program name en
Research Tools and Instruments - Category 1 (<$150,000)
Program name fr
Outils et instruments de recherche - catégorie 1 (<150 000$)
Group en
Discovery grants programs
Group fr
Programmes de subventions à la découverte
Committee code
1054
Committee name en
Mechanical Engineering - B
Committee name fr
Génie mécanique - B
Area of application code
1102
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Biomedical engineering
Area of application fr
Génie biomédical
Research subject code
2100
Research subject group en
Mechanical engineering
Research subject group fr
Génie mécanique
Research subject en
Mechanical engineering
Research subject fr
Génie mécanique
Partie
1
Nb partie
1
Application title
A microscale velocity measurement system for lab-on-a-chip applications
Keyword
NA
Application summary
The proposed research aims to develop micro-PIV technology for Lab-on-a-Chip (LOC) applications. A typical Lab-on-a-Chip device is a piece of glass or plastic plate with multiple chemical or biomedical laboratories integrated on it to perform micro-total-analysis. Lab-on-a-Chip devices have many advantages over their traditional counterparts including reduced expensive sample and reagent use, reduced processing time and space requirements, increased throughput and portability, and potentials for point-of-care diagnostics and treatment. However, the development of such attractive devices has been largely hindered due to the lack of the tools for precise design and operational control of the microfluidic platform, which holds and connects all the components of a LOC device. The major difficulty originates from the flow control of the microfluidic platform, which is dependent on solid-liquid interface properties. LOC devices include several components for sample preparation, mixing, dispensing, separation and detection, involving a variety of chemical solutions, biological samples, and chip materials. Therefore, the development of such devices requires a large database of the flow field information for each pair of solid-liquid interfaces. In addition, complex channel geometries and channel layouts make the flow field on a chip very complicated and the flow control very difficult. Micro particle image velocimetry is the only method for flow field measurement in the microscale and is essential for the development of LOC devices with the goal of developing point-of-care diagnostic instruments. The micro-PIV system, requested in this application, will provide urgently needed analytical resources to the research programs of Carolyn Ren and David Johnson. This setup will allow direct velocity measurement of the flow field in various microfluidic chips involving a variety of chemical solutions and samples. Fluorescent particles will be excited by a laser source and then detected by a CCD camera. The stored images will be analyzed using software on a computer to obtain the flow field.
