Grant: Project Grant
Centre for Addiction and Mental Health (Toronto)
$921,824.00
Endocannabinoid Metabolism in Individuals with Posttraumatic Stress Disorder: Neuroimaging Studies with the Novel Fatty Acid Amide Hydrolase Probe, [11C]CURB
EF 2017-18
Résumé
Fatty Acid Amide Hydrolase is the enzyme that regulates brain levels of the endogenous cannabinoid, anandamide, and it is a uniquely interesting target for the development of therapeutics for post-traumatic stress disorder (PTSD). The present multimodal brain imaging project will determine whether PTSD is associated with elevated levels of this enzyme in the brain and whether this contributes to abnormal functioning in brain circuits implicated in PTSD which process fear and threat. Results of this study will help develop pharmacological treatment for PTSD, a disorder that imposes a significant burden at the individual and societal level
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
369690
Name
Boileau Isabelle
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Clinical
Prcname2
Behavioural Sciences - B-2
Projecttitle
Endocannabinoid Metabolism in Individuals with Posttraumatic Stress Disorder: Neuroimaging Studies with the Novel Fatty Acid Amide Hydrolase Probe, [11C]CURB
Programtype2
Operating Grants
Orgnameinp2
Centre for Addiction and Mental Health (Toronto)
Cihramount2
$921,824
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Amygdala; Endocannabinoid; Fatty Acid Amide Hydrolase; Fmri; Positron Emission Tomography; Post Traumatic Stress Disorder; Threat
Abstract
Fatty Acid Amide Hydrolase is the enzyme that regulates brain levels of the endogenous cannabinoid, anandamide, and it is a uniquely interesting target for the development of therapeutics for post-traumatic stress disorder (PTSD). The present multimodal brain imaging project will determine whether PTSD is associated with elevated levels of this enzyme in the brain and whether this contributes to abnormal functioning in brain circuits implicated in PTSD which process fear and threat. Results of this study will help develop pharmacological treatment for PTSD, a disorder that imposes a significant burden at the individual and societal level
Competitiondate
201709
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Boileau, Isabelle
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $921,824~ $0~
