Grant: Proof of Principle Program - Phase I

Topical and oral administration of vitamin A or vitamin A-like drugs are often used in the treatment of skin disorders including severe acne. This treatment however can carry significant risks and side effects due to the broad range of effects of these drugs, and can be particularly harmful if taken during pregnancy. We propose to develop a safer method of treating these disorders by increasing local levels of vitamin A in the skin. We will do this by developing drugs that can inhibit the metabolic breakdown of vitamin A in skin cells, thereby allowing those cells to benefit from the helpful effects of vitamin A treatment, without the risk of adverse side effects.