Grant: Operating Grant
York University (Toronto, Ontario)
$584,060.00
Function of SMAD7 in growth and differentiation of skeletal muscle
EF 2012-13
Résumé
A variety of muscle diseases and ageing related muscle wasting result from a loss of muscle mass. We have discovered a gene called Smad7 which regulates skeletal muscle growth. So far these observations have been made in cultured muscle cells. In the proposed work we would like to develop this work further to understand how Smad7 has this effect on muscle cells and also to determine whether it fulfills the same function in living animals.
Programme
Operating Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
266205
Name
McDermott John C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Movement & Exercise
Projecttitle
Function of SMAD7 in growth and differentiation of skeletal muscle
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$584,060
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cell Biology; Growth; Mass Spectrometry; Proteomics
Abstract
A variety of muscle diseases and ageing related muscle wasting result from a loss of muscle mass. We have discovered a gene called Smad7 which regulates skeletal muscle growth. So far these observations have been made in cultured muscle cells. In the proposed work we would like to develop this work further to understand how Smad7 has this effect on muscle cells and also to determine whether it fulfills the same function in living animals.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McDermott, John C
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $584,060~ $0~
