Grant: Project Grant

Necrosis is prevalent during infection with virulent pathogens, which results in inflammation and compromised host susceptibility. Recently, several cell signaling platforms have been revealed which result in cell rupture and release of inflammatory mediators to the external milieu. Necrosome signaling platform is one such cell signaling platform which has been shown to play a key role in promoting deleterious responses during numerous chronic diseases. We have previously shown that proteins involved in necrosome activation induce sepsis, an inflammatory condition with a deadly outcome. Our current proposal is to decipher how necrosome signaling is induced and regulated so that we can identify specific downstream targets that can be targeted for therapy.