Grant: DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
University of Alberta
$120,000.00
Targeting renal blood flow to prevent sepsis-associated acute kidney injury
EF 2025-26
Résumé
Sepsis is a medical emergency where the body mounts an overwhelming response to infection. It has a very high mortality rate and is believed to be responsible for one in five deaths globally. Kidney damage is a common complication in sepsis, and when it occurs, patients have a greater chance of dying. This project aims to examine how blood flow to the kidney is affected in sepsis. We will also test a treatment to improve blood flow in the kidneys in sepsis, with the goal of reducing or altogether preventing kidney damage. We also aim to understand whether sepsis-associated kidney injury is fundamentally different in males and females. This study will provide new information about how sepsis affects the kidney and may lead to new treatments to prevent or treat kidney injury in septic patients.
Programme
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
559932
Name
Khodabocus Ibrahim
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
DT1 (Biomedical and/or Clinical Research) CGRS Doctoral
Projecttitle
Targeting renal blood flow to prevent sepsis-associated acute kidney injury
Programtype2
Studentship Programs
Orgnameinp2
University of Alberta
Cihramount2
$120,000
Cihrequipment2
$0
Programname2
DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)
Keyworddelim
Acute Kidney Injury; Cinaciguat; Hypoxemia; Hypoxia; Mitochondrial Dysfunction; Renal Cortex; Renal Medulla; Sepsis; Soluble Guanylate Cyclase Activation
Abstract
Sepsis is a medical emergency where the body mounts an overwhelming response to infection. It has a very high mortality rate and is believed to be responsible for one in five deaths globally. Kidney damage is a common complication in sepsis, and when it occurs, patients have a greater chance of dying. This project aims to examine how blood flow to the kidney is affected in sepsis. We will also test a treatment to improve blood flow in the kidneys in sepsis, with the goal of reducing or altogether preventing kidney damage. We also aim to understand whether sepsis-associated kidney injury is fundamentally different in males and females. This study will provide new information about how sepsis affects the kidney and may lead to new treatments to prevent or treat kidney injury in septic patients.
Competitiondate
202511
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Khodabocus, Ibrahim
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $120,000~ $0~
