Grant: Project Grant
University of Toronto
$1,005,320.00
Targeting Frizzled proteins in RNF43 mutant cancers.
EF 2015-16
Résumé
The Frizzled family of cell surface receptors become too abundant in a subset of pancreatic, colorectal and gastric cancers. This is due to mutations in a protein called RNF43, which function is to limit the number of Frizzled proteins. We have developed antibodies that can block the function of the super-numerous Frizzled in these cancers and showed that these antibodies block cancer progression in vitro and in vivo in mouse models. In this proposal our team will further develop these antibodies and determine their pre-clinical efficacy.
Programme
Project Grant
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
344842
Name
Angers Stephane
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Targeting Frizzled proteins in RNF43 mutant cancers.
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,005,320
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cancer; Cell Signalling; Colon Cancer; Synthetic Antibodies; Ubiquitin Ligase; Wnt
Abstract
The Frizzled family of cell surface receptors become too abundant in a subset of pancreatic, colorectal and gastric cancers. This is due to mutations in a protein called RNF43, which function is to limit the number of Frizzled proteins. We have developed antibodies that can block the function of the super-numerous Frizzled in these cancers and showed that these antibodies block cancer progression in vitro and in vivo in mouse models. In this proposal our team will further develop these antibodies and determine their pre-clinical efficacy.
Competitiondate
201603
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Angers, Stephane; Sidhu, Sachdev S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,005,320~ $0~
