Grant: Project Grant

Psoriasis is a common skin disease responsible for the formation of psoriatic plaques with a penalizing aesthetic aspect and various secondary effects such as arthritis. Whereas the link of the disease with the immune system is now well documented, the origin of the disease is still poorly understood. Our hypothesis is that the formation of psoriatic plaques is induced by a nervous stress, and cutaneous sensory nerves trigger locally an initial neuroinflammation leading to the formation of the psoriatic plaque. This process is promoted by the secretion by nerves of neuropeptides, and by epidermis of neurotrophic factors. Developing a new therapy aiming to inhibit this neurogenic inflammation could be very innovative and effective in the treatment of this disease, with minimal side effects.