Grant: Operating Grant

When a cell divides, a complex machine is built to accurately separate genetic material (DNA) into two daughter cells. This machine is called the mitotic spindle, due to its shape: a broad barrel, pointed on both ends. The spindle composed of mainly cable-like polymers called microtubules, which can connect to and move the DNA. We will study key protein molecules that interact with these polymers and understand how they are coordinated to build this DNA-segregation machine. Improper segregation of DNA can cause cells to have an abnormal amount of genetic material, an outcome often associated with cancer. Our cells have surveillance systems to monitor whether this DNA-segregating machine is properly assembled, they will not divide until the spindle is properly formed and connected to DNA. Since cancer is a disease of uncontrolled cell divisions, inhibiting spindle formation thus provides a way to block cells from dividing. Understanding how this DNA-segregation machine is built could help us to identify new targets for developing improved anti-cancer drugs.