Grant: CIHR Fellowship

Multiple sclerosis (MS) is a chronic disease that affects the central nervous system that leads to cognitive decline, loss of motor function, and vision problems. It is believed to be triggered by a combination of genetic factors and environmental influences, such as herpesvirus infection. Our immune system includes various types of cells, including natural killer (NK) cells, which help defend against infections and disease. NK cells encode receptors that are variably distributed throughout the immune compartment and differ greatly among individuals. These variations influence how our immune system reacts to infections and diseases such as MS. Here, we will examine whether genetic differences in NK receptors, their distribution, and their interaction with other molecules influence MS disease. This knowledge could identify individuals at higher risk for developing MS and will provide crucial knowledge to develop targeted treatments to manage MS disease.