Grant: Travel Awards - Institute Community Support

Colon cancer is one of the most common cancers worldwide, and many patients experience side effects such as muscle loss, weakness, and increased body fat. Research shows that regular physical activity is one of the most effective ways to improve muscle health and overall recovery after cancer treatment, but more evidence is needed to understand how and why it works. This study is part of the large international Canadian Cancer Trials Group CO.21 clinical trial, which showed improved survival in people treated for colon cancer after a three-year structured exercise program. This study analyzes the effects of exercise on muscle health and fat during the first year of the program. Using medical images (CT scans) taken at diagnosis and one year later, we can measure changes in muscle quality, muscle mass, and body fat. These detailed measurements go beyond simple weight or BMI, offering a more precise picture of how exercise influences the body after treatment. We expect that participants who followed the exercise program will increase their muscle strength, muscle mass, and physical function compared with those who received standard health education materials. The study will also be the first to apply a comprehensive, standardized definition of sarcopenia (low muscle mass and strength) in this group, helping identify how common this condition is among colon cancer survivors. By combining advanced imaging with physical assessments, this research will shed light on how exercise can improve long-term recovery, reduce treatment-related side effects, and help survivors live healthier, more active lives. By understanding the biological effects of exercise on muscle and fat, we aim to design better rehabilitation programs that reduce side effects, improve long-term health, and help cancer survivors live stronger, healthier lives. The results will guide future clinical recommendations and inform lifestyle-based strategies to support cancer survivorship in Canada and beyond.