Grant: Project Grant

Cardiac problems have become the first cause of maternal mortality in Canada. Transformations to the cardiovascular system during pregnancy may explain why some women experience new or sudden worsening of their cardiac problems in pregnancy. Atrial fibrillation (AF) is the most frequent type of heartbeat abnormality to occur in pregnancy. AF can be associated with serious maternal complications, such as heart failure and strokes. What we do not know is what proportion of women with AF in pregnancy will experience serious complications. In addition, blood thinners are a kind of medication that may be given to pregnant women with AF to prevent strokes. However, blood thinners can also lead to bleeding problems. Information is currently lacking about the safety and efficacy of these medications when given for AF in pregnancy. The objective of our study is to gain more knowledge on how best to care for pregnant women with AF. First, we will measure the proportion of women with AF with serious complications. We will also evaluate whether blood thinners are effective and safe medications to prevent strokes during pregnancy and the 6 weeks following delivery. To do so, we will analyse the anonymous information of patients in Canada and the United States with AF during pregnancy. The results of the proposed study will provide information about the specific healthcare needs of pregnant women with AF. In turn, this study will help to improve the care of pregnant and postpartum women with cardiovascular diseases.