Grant: Project Grant
University of Alberta
$650,250.00
Deciphering the USP7-UBE4B-p53 Axis in Cancer: Mechanistic Insights and Therapeutic Opportunities.
EF 2024-25
Résumé
The significance of the p53 tumor suppressor in cancer prevention is underscored by the fact that p53 is inactivated in over 50% of all human tumors. Proper regulation of p53 expression and stability is essential for maintaining normal cell growth. This regulation involves dynamic processes of ubiquitination and deubiquitination. Recently, deubiquitination has been recognized as a crucial mechanism in the regulation of p53. The research team led by Dr. Leng is particularly focused on three molecules: USP7, UBE4B, and p53, as they seem to play a role in tumor growth regulation. They propose to investigate the mechanisms underlying the roles and regulation of the UBE4B-p53 axis by USP7 in tumors. Using advanced molecular tools, they aim to study how these molecules interact to regulate p53. The results of this research could have significant implications and potential effects on cancer therapy.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
524847
Name
Leng Roger P
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Deciphering the USP7-UBE4B-p53 Axis in Cancer: Mechanistic Insights and Therapeutic Opportunities.
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$650,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Breast Cancer; Deubiquitination; Oncogene; P53; Tumor Suppressor; Ubiquitination; Usp7
Abstract
The significance of the p53 tumor suppressor in cancer prevention is underscored by the fact that p53 is inactivated in over 50% of all human tumors. Proper regulation of p53 expression and stability is essential for maintaining normal cell growth. This regulation involves dynamic processes of ubiquitination and deubiquitination. Recently, deubiquitination has been recognized as a crucial mechanism in the regulation of p53. The research team led by Dr. Leng is particularly focused on three molecules: USP7, UBE4B, and p53, as they seem to play a role in tumor growth regulation. They propose to investigate the mechanisms underlying the roles and regulation of the UBE4B-p53 axis by USP7 in tumors. Using advanced molecular tools, they aim to study how these molecules interact to regulate p53. The results of this research could have significant implications and potential effects on cancer therapy.
Competitiondate
202503
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Leng, Roger P
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $650,250~ $0~
