Grant: Project Grant
Research Institute of the McGill University Health Centre
$898,876.00
Identification of the mechanisms underlying the early stages of leukemogenesis in human hematopoietic stem cells.
EF 2021-22
Résumé
The goal of this project is to study how normal blood cells transition to an abnormal pre-cancerous cell that then progresses to a full cancer. Individuals can be otherwise healthy but carry mutations in blood cell stem cells that put them at risk for developing leukemia. We intend to generate models of how these specific mutations change the normal behavior of blood stem cells and the rest of the blood system.
We will introduce these mutations into normal blood cells and measure the effects on cellular processes in individual cells. This includes gene activity as well as the overall functional ability of individual cells. Finally, we will investigate potential drugs to target these pre-cancerous cells. This will increase our understanding of cancer development and stem cell biology and can enable improvements in therapy and cancer prevention.
Programme
Project Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
463108
Name
Eppert Kolja
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Identification of the mechanisms underlying the early stages of leukemogenesis in human hematopoietic stem cells.
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$898,876
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Acute Myeloid Leukemia; Hematopoiesis; Hematopoietic Stem Cell; Pre-Leukemia; Stem Cell Biology
Abstract
The goal of this project is to study how normal blood cells transition to an abnormal pre-cancerous cell that then progresses to a full cancer. Individuals can be otherwise healthy but carry mutations in blood cell stem cells that put them at risk for developing leukemia. We intend to generate models of how these specific mutations change the normal behavior of blood stem cells and the rest of the blood system.
We will introduce these mutations into normal blood cells and measure the effects on cellular processes in individual cells. This includes gene activity as well as the overall functional ability of individual cells. Finally, we will investigate potential drugs to target these pre-cancerous cells. This will increase our understanding of cancer development and stem cell biology and can enable improvements in therapy and cancer prevention.
Competitiondate
202203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Eppert, Kolja
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $898,876~ $0~
