Grant: Operating Grant

Cellular processes require a coordinated expression of specific sets of genes that control cell growth, division and signalling. Perturbation of gene expression causes human diseases including cancer. In my laboratory, we are identifying and studying genes that, when disturbed, prevent the proteins from assuming their normal functions thereby causing the many symptoms characteristic of the diseases. The identification of such genes and the elucidation of their functions in normal and cancer cells are the first step in approaching these important health problems and are important since these studies may lead to the development of new therapeutic strategies for treating human cancers.