Grant: DSEN team grants: MAGIC and CAN-AIM

In this proposal, we outline the composition, purpose, and future growth of the Canadian Institutes for Health Research (CIHR) Drug Safety and Effectiveness Network (DSEN) Methods and Applications Group for Indirect Comparisons (MAGIC) Team. The MAGIC team includes health methodologists and research scientists from universities and research centers across Canada, with internationally recognized expertise in knowledge synthesis, biostatistics, safety and effectiveness research, knowledge translation, sex and gender analysis, and health economics. The goal of MAGIC is to apply innovative research methods to produce trusted, timely, unbiased and clear evidence that inform policy decisions on post-market drug safety and effectiveness. Over the past 8 years, MAGIC has conducted 35 research projects for DSEN knowledge users (KUs) including Health Canada, Canadian Agency for Drugs and Technologies in Health (CADTH), and provincial/territorial ministries of health, while mentoring 23 trainees and delivering evidence-based KT products. MAGIC remains firmly focused on its primary objective to enhance Canadian pharmacovigilance, the healthcare system, and the health of all Canadians by continuing to generate rigorous knowledge synthesis products for DSEN, including all types of reviews and analyses, and primary data collection, as needed, to best inform DSEN's KUs and meet their evidence needs. MAGIC aims to use our research findings to influence capacity-building and health research methods across Canada, and globally. Our capacity-building and networking strategies will allow our trainees and new investigators to develop skills in this rapidly evolving field and will contribute to the creation of highly qualified personnel in Canada who will continue to work in academic, industry or policy fields on post-market drug safety and effectiveness.