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Grant: Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

University of British Columbia

$167,056.00

Peptide macrocycle decoys against COVID-19 viral spike protein

EF 2020-21

Résumé
Peptides are potent, easy-to-synthesize, and synthetically accessible molecules that can specifically interact with pathogens. Peptides have been used to treat diabetes, neuropathic pain, cancer, and HIV. As chemists we have very recently invented news ways to make peptides both more potent as well as fluorescent in order to see where they go and how they act. We are poised to interface our technology with molecular modelling to synthesize peptides that will intercept the virus before it can enter a cell. These peptides can be injected or nasally delivered for therapy and can be used prior to vaccine development or in cases where certain patients cannot be vaccinated.
Programme
Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database

Tel que publié

Id
429721
Name
Perrin David M
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
COVID-19 Rapid Research - Therapeutics
Projecttitle
Peptide macrocycle decoys against COVID-19 viral spike protein
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$167,056
Cihrequipment2
$0
Programname2
Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics
Keyworddelim
Chemistry; Drug Design; Macrocycle; Peptide; Peptide Staple; Protein Recognition
Abstract
Peptides are potent, easy-to-synthesize, and synthetically accessible molecules that can specifically interact with pathogens. Peptides have been used to treat diabetes, neuropathic pain, cancer, and HIV. As chemists we have very recently invented news ways to make peptides both more potent as well as fluorescent in order to see where they go and how they act. We are poised to interface our technology with molecular modelling to synthesize peptides that will intercept the virus before it can enter a cell. These peptides can be injected or nasally delivered for therapy and can be used prior to vaccine development or in cases where certain patients cannot be vaccinated.
Competitiondate
202005
Approvedterm2
1 yr 0 mth
Pinamesdelim
Perrin, David M
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $167,056~ $0~