Grant: Operating Grant
McGill University
$699,673.00
Transcription and Translesion Synthesis
EF 2008-09
Résumé
Cancer is believed to be caused by the accumulation of mutations that cause the activation of oncogenes and the inactivation of tumor suppressors. While much progress has been made in the elucidation of various mechanisms of DNA repair, very little is known about the processes by which point mutations are introduced in our genome. The aim of this proposal is to verify whether the rate of mutagenesis can vary in response to certain treatments and to investigate a mechanism by which error-prone DNA polymerases are targeted to specific genomic regions.
Programme
Operating Grant
Bénéficiaire
Emplacement
Quebec, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
181301
Name
Nepveu Alain
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Transcription and Translesion Synthesis
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$699,673
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cux1; Genomic Analysis; Ku; Point Mutations; Post-Translational Modifications; Rev1; Transcriptional Regulation; Translesion Synthesis
Abstract
Cancer is believed to be caused by the accumulation of mutations that cause the activation of oncogenes and the inactivation of tumor suppressors. While much progress has been made in the elucidation of various mechanisms of DNA repair, very little is known about the processes by which point mutations are introduced in our genome. The aim of this proposal is to verify whether the rate of mutagenesis can vary in response to certain treatments and to investigate a mechanism by which error-prone DNA polymerases are targeted to specific genomic regions.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Nepveu, Alain
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $699,673~ $0~
