Grant: Project Grant

Although multiple treatments for HIV-1 exist, none cure this infection nor deal with the side effects such as chronic inflammation that reduce the quality of life of those infected. To address these shortcomings, my group has been investigating novel strategies to regulate the expression of viral genes. Our studies have demonstrated an ability to enhance or inhibit HIV-1 expression that could form the basis for a "functional cure" as well as limit the chronic inflammation associated with this infection. Experiments detailed in this application are aimed at increasing our understanding of the responses observed to enhance efficacy and limit off target effects of the anti-HIV strategies developed.