Grant: Research Tools and Instruments - Category 1 (<$150,000)

The funds from the enclosed NSERC Research Tools and Instruments (RTI) grant will be used to create necessary infrastructure for separating and isolating subcellular compartments including an ultracentrifuge and a sucrose density fractionator for the Chemistry & Biochemistry department at the University of Windsor. The research projects of the primary users that will benefit from this instrument include characterizing the role of a putative oncoprotein in ribosome biogenesis, studies on the role of cell membrane composition during cell stress and understanding the processes by which parasites invade cells. Furthermore, since this will be the only large volume ultracentrifuge and density gradient fractionators on the entire campus, numerous research laboratories from many different disciplines and departments will now be able to perform routine subcellular fractionation procedures for their research programs. The primary users urgently require the proposed infrastructure for the training goals proposed in Univ. of Windsor's only NSERC CREATE proposal, to accomplish objectives listed in the NSERC Discovery Grants of the applicant and co-applicants, CIHR objectives of the applicant, and for routine subcellular fractionation needs of research laboratories in the Chemistry and Biochemistry department as well as other departments at the University of Windsor.