Grant: Operating Grant
Research Institute of the McGill University Health Centre
$629,130.00
The human growth hormone receptor: regulation of expression during development
EF 2011-12
Résumé
Growth is a complex process, regulated by numerous genes as well as nutritional and environmental factors. Growth hormone (GH) is known to play an essential role in the growing child as well as the adult, through multiple growth-promoting as well as metabolic effects, by binding to its specific receptor (GHR) on target cells. Thus, the ability of GH to exert its actions is intimately linked to the availability of its receptor. Our objective is to identify and characterise the regions within the GHR gene that are responsible for controlling GHR expression in GH target tissues. This "biological blueprint" will provide the basis for understanding the mechanisms whereby tissue GHR levels change during normal development and differ from one individual to another. In addition, our investigations will pinpoint areas within the GHR gene to examine for the presence of genetic alterations in individuals at all ages who exhibit decreased responsiveness to GH (e.g. abnormal postnatal growth, obesity) or enhanced GH responsiveness (e.g. cancer progression).
Programme
Operating Grant
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
238095
Name
Goodyer Cynthia G
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Endocrinology
Projecttitle
The human growth hormone receptor: regulation of expression during development
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$629,130
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Fetal And Postnatal Growth; Gene Expression; Gene Regulation; Growth Disorders; Growth Hormone Receptor; Intracellular Signaling Pathways; Micrornas; Molecular Biology; Regulatory Polymorphisms; Truncated Growth Hormone Receptor
Abstract
Growth is a complex process, regulated by numerous genes as well as nutritional and environmental factors. Growth hormone (GH) is known to play an essential role in the growing child as well as the adult, through multiple growth-promoting as well as metabolic effects, by binding to its specific receptor (GHR) on target cells. Thus, the ability of GH to exert its actions is intimately linked to the availability of its receptor. Our objective is to identify and characterise the regions within the GHR gene that are responsible for controlling GHR expression in GH target tissues. This "biological blueprint" will provide the basis for understanding the mechanisms whereby tissue GHR levels change during normal development and differ from one individual to another. In addition, our investigations will pinpoint areas within the GHR gene to examine for the presence of genetic alterations in individuals at all ages who exhibit decreased responsiveness to GH (e.g. abnormal postnatal growth, obesity) or enhanced GH responsiveness (e.g. cancer progression).
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Goodyer, Cynthia G
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $629,130~ $0~
