Grant: Travel Awards - Institute Community Support
Institut de recherches cliniques de Montréal
$1,000.00
AXL is a central mediator of HER2+ breast cancer metastasis
EF 2015-16
Résumé
It has been previously demonstrated that the AXL protein is involved in motility of cancer cells to form secondary tumors in distant organ (metastasis) and it is known that the metastasis causes 90% of cancer related deaths. Our goal is to study the mechanism by which AXL allows metastasis using mice that develop breast cancer in which we removed the AXL protein. Also, a study of the permeability of the tumor blood vessels will be performed, since permeable vessels are more permissive to let cancer cell enter the blood circulation. Through this study, it will be possible to learn about the mechanism of action AXL and make it an important target for the treatment of metastatic cancers.
Programme
Travel Awards - Institute Community Support
Bénéficiaire
Emplacement
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
331762
Name
Goyette Marie-Anne
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Institute of Cancer Research
Projecttitle
AXL is a central mediator of HER2+ breast cancer metastasis
Programtype2
Undefined
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Angiogenesis; Axl; Breast Cancer; Her2; Knock Out Mouse; Metastasis; Mouse Models
Abstract
It has been previously demonstrated that the AXL protein is involved in motility of cancer cells to form secondary tumors in distant organ (metastasis) and it is known that the metastasis causes 90% of cancer related deaths. Our goal is to study the mechanism by which AXL allows metastasis using mice that develop breast cancer in which we removed the AXL protein. Also, a study of the permeability of the tumor blood vessels will be performed, since permeable vessels are more permissive to let cancer cell enter the blood circulation. Through this study, it will be possible to learn about the mechanism of action AXL and make it an important target for the treatment of metastatic cancers.
Competitiondate
201505
Approvedterm2
1 yr 0 mth
Pinamesdelim
Goyette, Marie-Anne
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,000~ $0~
