Grant: Operating Grant

Males and females have different outcomes in blood cancer, with males being twice as more susceptible to develop a blood cancer. However a clear molecular link to explain this sex-specific difference is still missing. Our goal is to better understand the reasons for the sex differences in the occurrence of hematologic malignancies. We recently uncovered an aberrantly regulated molecular pathway involved in blood cancer susceptibility affecting predominantly males. We hope that by understanding the molecular pathways involved in the sex-specific effect in blood cancer susceptibility, we will be able to design and implement preventive measures specific for the high-risk population.