Grant: Canada Research Chairs
Université d'Ottawa
$200,000.00
Genomics and the Environment
EF 2023-24
Résumé
This research program addresses an urgent need to modernize human health risk assessment of environmental chemicals to increase efficiency, reduce cost, and reduce the large numbers of animals required for toxicological testing. The main objective is to develop and deploy approaches that quantify how toxic chemicals can modulate the function of genes or damage genetic material (ie, genomics), and use this information to predict toxicological effects in humans. The program bridges basic and applied sciences, bringing together the research and regulatory communities in academia and government to advance regulatory processes and decision-making.
Programme
Canada Research Chairs
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
CRC-2020-00060
Name nom
Yauk, Carole
Department département
Biology - University of Ottawa
Organization id
28
Institution établissement
Université d'Ottawa
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2020
Award amount
200000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
10000
Research subject group en
The field of research available
Research subject group fr
The field of research available
Research subject en
Le domaine de recherche disponible
Research subject fr
Le domaine de recherche disponible
Field of research list codes
RDF10605;RDF30302
Field of research list names en
Biological evolution;Public and population health
Field of research list names fr
Biologie de l'évolution;Santé publique et santé des populations
Application title
Genomics and the Environment
Keyword
toxicogenomics
genetic toxicology
genomics
genetics
mutation
mutagenesis
toxicology
risk assessment
regulatory toxicology
next-generation sequencing
germ cell mutation
public health
dose-response analysis
benchmark dose
adverse outcome pathway
mechanistic toxicology
new approach methodologies
high-throughput screening
transcriptomics
Application summary
This research program addresses an urgent need to modernize human health risk assessment of environmental chemicals to increase efficiency, reduce cost, and reduce the large numbers of animals required for toxicological testing. The main objective is to develop and deploy approaches that quantify how toxic chemicals can modulate the function of genes or damage genetic material (ie, genomics), and use this information to predict toxicological effects in humans. The program bridges basic and applied sciences, bringing together the research and regulatory communities in academia and government to advance regulatory processes and decision-making.
