Grant: Applied Research and Development Grants - Level 1
Lambton College of Applied Arts and Technology
$25,000.00
Optimization of Fermentation and Purification Processes for the Production of Linear Covalently Closed DNA Ministrings
EF 2018-19
Résumé
Safer DNA vectors with high stability, efficacy and efficient purification are of high demand in the gene therapy (GT) industry as a delivery device for genetic cargo. To date, while many vector approaches have been applied to GT, they have fallen short in vector expression delivery, duration and gene expression efficiency, and safety.*Mediphage Bioceuticals, a start-up company that utilizes bacteriophage and/or bacteriophage elements to develop platform technologies for gene therapeutics is partnering with Lambton College's Bio-industrial Process Research centre is to optimize a fermentation and purification process for the production of linear covalently closed DNA minivectors.*The Lambton College research team that will work closely with Mediphage Bioceuticals includes a principal investigator and two research students. The results of the project will relieve the msDNA production bottleneck and provide an efficacious and safe approach to cell engineering, as well as ensure a stable and inexpensive supply of vector to enable new cell and gene therapies.*
Programme
Applied Research and Development Grants - Level 1
Bénéficiaire
Emplacement
Ontario, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
NSERC's Awards Data
Tel que publié
Application id
522225-2017
Name nom
Sheikhzadeh, Mehdi
Department département
Head Office
Organization id
26621
Institution établissement
Lambton College of Applied Arts and Technology
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2018
Competition year année de concours
2017
Award amount
25000
Program id
CARD1
Program name en
Applied Research and Development Grants - Level 1
Program name fr
Subventions de recherche et développement appliquée - niveau 1
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
1561
Committee name en
Applied Research and Development Grants
Committee name fr
Subventions de recherche et développement appliquée
Area of application code
504
Area of application group en
Manufacturing processes and products
Area of application group fr
Procédés et produits industriels
Area of application en
Human pharmaceuticals
Area of application fr
Produits pharmaceutiques administrables à l'homme
Research subject code
1901
Research subject group en
Biomedical engineering
Research subject group fr
Génie biomédical
Research subject en
Biomedical technology
Research subject fr
Technologie biomédicale
Partie
1
Nb partie
1
Application title
Optimization of Fermentation and Purification Processes for the Production of Linear Covalently Closed DNA Ministrings
Keyword
NSERC
Application summary
Safer DNA vectors with high stability, efficacy and efficient purification are of high demand in the gene therapy (GT) industry as a delivery device for genetic cargo. To date, while many vector approaches have been applied to GT, they have fallen short in vector expression delivery, duration and gene expression efficiency, and safety.*Mediphage Bioceuticals, a start-up company that utilizes bacteriophage and/or bacteriophage elements to develop platform technologies for gene therapeutics is partnering with Lambton College's Bio-industrial Process Research centre is to optimize a fermentation and purification process for the production of linear covalently closed DNA minivectors.*The Lambton College research team that will work closely with Mediphage Bioceuticals includes a principal investigator and two research students. The results of the project will relieve the msDNA production bottleneck and provide an efficacious and safe approach to cell engineering, as well as ensure a stable and inexpensive supply of vector to enable new cell and gene therapies.*
