Grant: Project Grant
University of British Columbia
$535,500.00
Regulation of chromatin structure on transcribed genes and newly replicated DNA
EF 2018-19
Résumé
In eukaryotes, DNA is packaged into a nucleoprotein structure known as chromatin, which is critical for gene regulation and genome stability. The FACT (FAcilitates Chromatin Transactions) complex is an abundant and conserved complex that is essential for maintenance of chromatin structure in dividing cells. As a result, cancer cells, but not normal cells, require FACT for viability. Despite progress in the development of FACT-targeting anticancer therapies, fundamental questions regarding FACT function remain unanswered. In our proposed research we will uncover the molecular mechanisms for the regulation of chromatin structure by FACT.
Programme
Project Grant
Bénéficiaire
Emplacement
British Columbia, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
388470
Name
Howe Leann J
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Regulation of chromatin structure on transcribed genes and newly replicated DNA
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$535,500
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chromatin,; Dna Replication; Facilitates Chromatin Transactions Complex; Histone; Nucleosome; Transcription
Abstract
In eukaryotes, DNA is packaged into a nucleoprotein structure known as chromatin, which is critical for gene regulation and genome stability. The FACT (FAcilitates Chromatin Transactions) complex is an abundant and conserved complex that is essential for maintenance of chromatin structure in dividing cells. As a result, cancer cells, but not normal cells, require FACT for viability. Despite progress in the development of FACT-targeting anticancer therapies, fundamental questions regarding FACT function remain unanswered. In our proposed research we will uncover the molecular mechanisms for the regulation of chromatin structure by FACT.
Competitiondate
201809
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Howe, Leann J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $535,500~ $0~
