Grant: Project Grant
University of Alberta
$803,250.00
Molecular switch function in a prion protein; control of pathways leading to pathogenesis or disease remediation
EF 2018-19
Résumé
Neurodegenerative diseases are an enormous and growing public health concern yet they lack interventions that go beyond symptomatic relief to be mechanism-based. This project will target a) the pathways by which PrP, a cell-surface protein, determines detrimental outcomes in prion diseases, Alzheimer's Disease and Parkinson's disease, b) seek novel small molecules that blunt the disease-causing potential of PrP molecules and c) investigate how a small molecule partner (a vitamin) interacts with PrP.
Programme
Project Grant
Bénéficiaire
Emplacement
Alberta, Canada
Type de bénéficiaire
Academia
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
401143
Name
Westaway David
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Cell Biology - Disease
Projecttitle
Molecular switch function in a prion protein; control of pathways leading to pathogenesis or disease remediation
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$803,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Alzheimer Disease; Nervous System; Neuronal Proteases; Nuclear Magnetic Resonance; Parkinson'S Disease; Prion Disease; Protein Folding; Reversed Genetics; Vitamins
Abstract
Neurodegenerative diseases are an enormous and growing public health concern yet they lack interventions that go beyond symptomatic relief to be mechanism-based. This project will target a) the pathways by which PrP, a cell-surface protein, determines detrimental outcomes in prion diseases, Alzheimer's Disease and Parkinson's disease, b) seek novel small molecules that blunt the disease-causing potential of PrP molecules and c) investigate how a small molecule partner (a vitamin) interacts with PrP.
Competitiondate
201903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Westaway, David
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $803,250~ $0~
