Grant: Fellowship: Priority Announcement - Clinical Nutrition
Queen's University (Kingston, Ontario)
$45,000.00
The role of dietary fermentable carbohydrates (FODMAPs) in the pathophysiology of inflammatory bowel disease
EF 2017-18
Résumé
Symptoms such as abdominal pain, bloating, diarrhea and constipation are common for patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Unfortunately, these gut symptoms cause significant disruption to the daily life of patients and can affect their ability to leave the home. These symptoms can be particularly troublesome in patients whose IBD is in remission but have ongoing IBS-like symptoms. The financial and social cost is huge.
For many years patients have asked their doctors if there is a particular diet that could help control their symptoms. Thankfully recent research has shown that a particular dietary therapy can be effective in reducing these gut symptoms in IBS patients. This dietary therapy is called 'the low FODMAP diet'. This diet involves avoiding certain foods containing short-chain fermentable carbohydrates (FODMAPs) with evidence suggesting it is helpful in 3 out of 4 patients with IBS. It has been recognized that 40% of patients with IBD in remission suffer from IBS-like symptoms. There is now some suggestion that the diet also helps these patients. However, it is unclear which patients will respond to the diet, how the diet may impact inflammation as occurs in IBD, and if there are any safety problems associated with the diet.
The overall aim of this research proposal is to understand the effects of fermentable carbohydrates (FODMAPs) on inflammation, symptoms and safety in patients with IBD in remission that have ongoing IBS-like symptoms. Specifically, this research aims to assess if an individual's gut bacteria can predict who will respond to the diet; if the diet is able to improve inflammation; if the diet improves symptoms; and finally if the dietary restrictions cause any safety problems such as reduced nutritional adequacy. Findings from this research will lead to development of individualized dietary therapies to reduce the burden of gut symptoms in patients with IBD and co-existing IBS-like symptoms
Programme
Fellowship: Priority Announcement - Clinical Nutrition
Bénéficiaire
Emplacement
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
Tel que publié
Id
379121
Name
Tuck Caroline J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Canadian Nutrition Society (Ottawa, Ontario)
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Fellowships - Post-PhD
Projecttitle
The role of dietary fermentable carbohydrates (FODMAPs) in the pathophysiology of inflammatory bowel disease
Programtype2
Fellowship Programs
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$45,000
Cihrequipment2
$0
Programname2
Fellowship: Priority Announcement - Clinical Nutrition
Keyworddelim
Carbohydrates; Diet; Dietary Therapy; Fermentable Carbohydrates; Fodmaps; Inflammatory Bowel Disease; Irritable Bowel Syndrome
Abstract
Symptoms such as abdominal pain, bloating, diarrhea and constipation are common for patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Unfortunately, these gut symptoms cause significant disruption to the daily life of patients and can affect their ability to leave the home. These symptoms can be particularly troublesome in patients whose IBD is in remission but have ongoing IBS-like symptoms. The financial and social cost is huge.
For many years patients have asked their doctors if there is a particular diet that could help control their symptoms. Thankfully recent research has shown that a particular dietary therapy can be effective in reducing these gut symptoms in IBS patients. This dietary therapy is called 'the low FODMAP diet'. This diet involves avoiding certain foods containing short-chain fermentable carbohydrates (FODMAPs) with evidence suggesting it is helpful in 3 out of 4 patients with IBS. It has been recognized that 40% of patients with IBD in remission suffer from IBS-like symptoms. There is now some suggestion that the diet also helps these patients. However, it is unclear which patients will respond to the diet, how the diet may impact inflammation as occurs in IBD, and if there are any safety problems associated with the diet.
The overall aim of this research proposal is to understand the effects of fermentable carbohydrates (FODMAPs) on inflammation, symptoms and safety in patients with IBD in remission that have ongoing IBS-like symptoms. Specifically, this research aims to assess if an individual's gut bacteria can predict who will respond to the diet; if the diet is able to improve inflammation; if the diet improves symptoms; and finally if the dietary restrictions cause any safety problems such as reduced nutritional adequacy. Findings from this research will lead to development of individualized dietary therapies to reduce the burden of gut symptoms in patients with IBD and co-existing IBS-like symptoms
Competitiondate
201711
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Tuck, Caroline J
Approvedterm
2 ans 0 mois
Cihrcontribution2
Inst of Nutr Metabolism &Diab~ $45,000~ $0~
